Research Focus
Bioreactors

Bioreactors provide technology platforms for the production of regenerative mediators by working cells. They also enable cell multiplication to provide transplantable reparative cells, and they are being developed for extracorporeal organ support using cell cultures.

3D technologies support tissue formation at a high cell density in vitro. Decentralized medium perfusion with low gradients and integrated oxygenation allow cell maintenance, differentiation or growth in vitro. Specific cells of the tissues are co-cultured to enable cellular communication and mediator exchange in the bioreactor. Our bioreactors provide the environment needed for the inoculated cells to spontaneously re-assemble to tissue-like structures and also support the re-formation of the vascular channels to supply the cells. Advanced systems support the culture and expansion/differentiation of stem cells.

To better understand the control of stem cell differentiation, physical factors of the cellulat macro environment and 3D cell-cell interactions at tissue densities have to be studied.

in vitro techniques advance from static 2D to dynamic perfusion culture, serving the functions of the organ’s vasculature. These physically active scaffolds provide a more physiologic supply in the cell macro environment; encluding homeostasis of oxygen, pH, electrolyte, nutrition, soluble factors, and gradients of metabolites.

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