About
Publications

• Bioreactor development
  
  Bioreactor development
  
  

  • Zeilinger K, Roth S, Witaschek T, Pfaff M, Toepfer S, Guthke R, Neuhaus P, Gerlach JC. Kinetic analysis of the electrolyte distribution in a perfused 3D-bioreactor for high-density liver cell culture. Biomed Eng 2005, 50 (Suppl. 1), 951-952
  • Pfaff M, Toepfer S, Zeilinger K, Roth S, Driesch D, Woetzel D, Schmidt-Heck W, Guthke R, Witaschek T, Gerlach JC. Systems analysis of the dynamic input/output behaviour of a multi-compartment capillary membrane bioreactor for high-density liver cell culture. Biomed Eng 2005, 50 (Suppl. 1), 1617-1618
  • Zeilinger K, Holland G, Sauer IM, Efimova E, Kardassis D, Obermayer N, Liu M, Neuhaus P, Gerlach J. Time course of primary liver cell reorganization in three-dimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study. Tissue Eng 2004, 10(7): 1113-1124.
  • Sauer IM, Schwartländer R, Van der Jagt O, Steffen I, Efimova E, Pless G, Kehr DC, Kardassis D, Fruhauf JH, Gerlach JC, Neuhaus P. In vitro evaluation of the transportability of viable primary human liver cells originating from discarded donor organs in bioreactors. Artif Organs. 2005 Feb;29(2):144-51.
  • Schmidt-Heck W, Zeilinger K, Pfaff M, Toepfer S, Driesch D, Pless, G, Neuhaus P, Gerlach J, Guthke R. Network analysis of the kinetics of amino acid metabolism in a liver cell bioreactor. J.M. Barreiro et al. (Eds): ISBMDA 2004, LNCS 3337: 427-438
  • Catapano G, Euler M, Gaylor J D S, Gerlach J. Characterization of the distribution of matter in hybrid liver support devices where cells are cultured in a 3-D membrane network or on flat substrata. Int J Artif Organs 2001; 24: 102-109
  • Kardassis D, Busse B, Besseling A, Krämer M, Puhl G, Spatkowski G, Holland G, Schnoy N, Müller C, Neuhaus P, Gerlach J. Enzyme release in hybrid liver support systems: Marker for Quality prior to clinical application. Transplantation Proceedings 1999;31: 668-669
  • Busse B; Gerlach J. The Berlin extracorporeal liver support system. In: The Hepatocyte Review. Edt. Berry MN; Edwards AM. Kluwer Academic Publishers, Dordrecht (NL) 1999
  • Gerlach J. Hepatocyte culture and bioreactor design for liver support systems. In: Williams R, Lee WM. Acute Liver Failure, Cambridge 1996: 245-254
  • Gerlach J. Development of a Hybrid Liver Support System - a review. Int J Art Org 1996;Â19:645-655
  • Gerlach J, Fuchs M, Smith M, Bornemann R, Neuhaus P, Riedel E. Is a clinical appliÂcation of hybrid liver support systems limited by an initial disorder in cellular amino acid and _-keto acid metabolism, rather than by later gradual loss of primary hepatocyte funcÂtion? Transplantation 1996;62:224-228
  • Gerlach J, Stoll P, Schnoy N, Neuhaus P. Comparison of hollow fibre membranes for hepatocyte immobilisation in bioreactors. Int J Art Org 1996;19:610-616
  • Gerlach J, Schnoy N, Encke J, Müller C, Smith M, Neuhaus P. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies. Hepatology 1995;22:546-552
  • Fuchs M, Gerlach J, Unger J, Encke J, Smith M, Neuhaus P, Riedel E. Amino acid metabolism by hepatocytes in a hybrid liver support bioreactor (rapid communication). Int J Art Org 1994;17:663-670
  • Gerlach J, Encke J, Hole O, Müller C, Ryan CJ, Neuhaus P. Bioreactor for larger scale hepatocyte in vitro perfusion. Transplantation 1994;58:984-988
  • Gerlach J, Neuhaus P. Culture model for primary hepatocytes. In Vitro Cell Dev Biol 1994;30A:640-642
  • Gerlach J. Use of hepatocyte cultures for liver support bioreactors. In: Felipo V, Grisolia S. Hepatic encephalopathy, hyperammonemia and ammonia toxicity. Plenum Press, New York, 1994:165-171
  • Gerlach J, Schnoy N, Smith M, Neuhaus P. Hepatocyte culture between woven capillary networks - a microscopy study. Art Org 1994;18:226-230
  • Gerlach J, Encke J, Hole O, Müller C, Courtney J, Neuhaus P. Hepatocyte culture between three dimensional arranged biomatrix- coated independent artificial capillary systems and sinusoidal endothelial cell co-culture compartments. Int J Art Org 1994;17: 301-306
  • Gerlach J, Klöppel K, Müller C, Schnoy N, Smith M, Neuhaus P. Hepatocyte aggregate culture technique for bioreactors in hybrid liver support systems. Int J Art Org 1993;16/12:843-846
  • Gerlach J, Klöppel K, Stoll P, Vienken J, Müller Ch, Schauwecker HH. Gas supply across membranes in bioreactors for hepatocyte culture. Art Org 1990;14:328-333
  • Gerlach J, Vienken J, Walker P, Affelt K. Computer aided time-lapse video analysis of hepatocyte morphology during adhesion to cellulose membranes. Int J Art Org 1990;13:365-369
  • Gerlach J, Stoll P, Schnoy N, Bücherl ES. Membranes as substrates for hepatocyte adhesion in liver support bioreactors. Int J Art Org 1990;13:436-441
  • Gerlach J, Schauwecker HH, Klöppel K,Tauber R, Müller Ch, Bücherl ES. Use of hepatocytes in adhesion and suspension cultures for liver support bioreactors. Int J Art Org 1989;12:788-793
  • Gerlach JC. Bioreactors for Extracorporeal Liver Support. Cell Transplantation 2006,15:1-8.
  • Catapano G, Gerlach JC. Bioreactors for liver tissue engineering. E-book "Topics in Tissue Engineering" Volume 2; 2006
  • Guthke R, Schmidt-Heck W, Pless G, Gebhardt R, Pfaff M, Gerlach JC, Zeilinger K. Dynamic model of amino acid and carbohydrate metabolism in primary human liver cells. M. Maglaveras et al. (Eds.): Springer Verlag 2006, ISBMDA 2006, LNBI 4345;137-149.

  
  
• Liver cell isolation
  
  Liver cell isolation
  
  

  • Gerlach J, Spatkowski G, Zeilinger K, Kolbeck S, Schnoy N, Neuhaus P. Large scale isolation of sinusoidal endothelial cells from pig and human liver. Surg Res. 100; 2001: 39-45
  • Gerlach J, Brombacher J, Smith M, Neuhaus P. High yield hepatocyte isolation from pig livers for investigation of hybrid liver support systems: Influence of collagenase concenÂtraÂtion and body weight. J Surg Res 1996;62: 85-89
  • Gerlach J, Brombacher J, Klöppel K, Smith M, Schnoy N, Neuhaus P. Comparison of four methods for mass hepatocyte isolation from pig and human livers. Transplantation 1994;57:1318-1322
  • Gerlach J, Klöppel K, Schön MR, Brombacher J, Courtney JM, Unger J, Neuhaus P. Comparison of pig hepatocyte isolation using intraoperative perfusion without warm ischemia and isolation of cells from abattoir organs after warm ischemia. Art Org 1993;17: 950-953
  • Gerlach J, Brombacher J, Courtney JM, Neuhaus P. Nonenzymatic versus enzymatic hepatocyte isolation from pig livers for larger scale investigations of liver cell perfusion systems. Int J Art Org 1993;16:677-681
  • Gerlach J. Section D: Hepatocytes and gastroenterology cells. In: Ricordi C: Methods in cell transplantation. Laundes, Austin/ Texas, USA 1995: 235-247

  
  
• Hepatocyte metabolism
  
  Hepatocyte Mutabolism
  
  

  • Guthke R, Zeilinger K, Sickinger S, Schmidt-Heck W, Buentemeyer H, Iding K, Lehmann J, Pless G, Gerlach JC. Dynamics of amino acid metabolism of primary human liver cells in 3D-bioreactors. Bioprocess Biosyst Eng. 2006 Apr;28(5):331-40. Epub 2006 Mar 21.
  • Kremling A, Zeilinger K, Gerlach JC, Gilles ED. A reduced stochiometric model to describe metabolism in hepatocytes. Proceedings of the International Conference on Control Applications (IEEE) 2006, in press
  • Klingmüller U, Bauer A, Bohl S, Nickel P, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Götschel F, Hecht A, Walter D, Egger L., Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Kleemann WJ, Zeilinger K, Heinrich M, Zanger UM, Reuss M, Bader A, Gebhardt R, Maiwald T, Timmer J, von Weizsäcker F, Hengstler JG. _Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. IEE Proc Systems Biology, 2006, in press
  • Schmidt-Heck W, Zeilinger K, Pless G, Gerlach Pfaff M, Guthke R. Prediction of the performance of human liver cell bioreactors by donor organ data. In: JL Oliveira et al., (Eds.): ISBMDA 2005, Lect Notes Comput Sc (LNBI) 3745, Springer-Verlag Berlin Heidelberg, 2005, 3745; 109 Ð 119, 12:805-810

  
  
• Endothelial cells
  
  Endothelial cells
  
  

  • Gerlach J, Kreusel KM, Schauwecker HH. Cell application into hybrid prostheses. Art Org 1991;14:139-142
  • Gerlach J, Schauwecker HH, Planck H. Polyurethanes and their cytocompatibility for cell seeding. In: Planck H. Medical textiles for implantation. Berlin/ Heidelberg 1990: 187-191
  • Gerlach J, Westmeyer K, Schauwecker HH, Kreusel KM, Bücherl ES. Isolation of vascular endothelial cells for investigations on hybrid prostheses. Int J Art Org 1989; 12:805-810
  • Gerlach J, Schauwecker HH, Hennig E, Bücherl ES. Endothelial cell seeding on different polyurethanes. Art Org 1989;13:144-147
  • Gerlach J, Kreusel KM, Schauwecker HH, Bücherl ES. Endothelial cell seeding on PTFE vascular prostheses using a standardized seeding technique. Int J Art Org 1989; 12:270-274
  • Gerlach JC, Hentschel F, Spatkowski G, Zeilinger K, Smith MD, Neuhaus P. Cell detachment during sinusoidal reperfusion after liver preservation - an in vitro model. Transplantation 1997; 64:907-912
  • Gerlach JC, Ziemer RA, Spatkowski G, Zeilinger K, Neuhaus P. Visualization of liver sinusoidal endothelial cell repair behavior after preservation by in vitro time-lapse video microscopy. Transplantation 1997;63:455-459
  • Gerlach J. Hybride Organe und hybride Organunterstützungssysteme. In: Bücherl ES. Künstliche Organe. Darmstadt, Wiss. Buchgesellschaft 1995: 82-106

  
  
• Stem cell culture models
  
  Stem cell culture models
  
  

  • Monga, PS, Hout MS, Baun MJ, Micsenyi A, Muller P, Tummalapalli L, Ranade AR, Strom SC, Gerlach JC. Mouse Fetal Liver Cells in Artificial Capillary Beds in Three-Dimensional Four-Compartment Bioreactors. Am J Pathol 2005;167:1279-1292
  • Zeilinger K, Hout MS, Gerlach JC. Strategies for the Therapeutic Use of Adult Stem Cells in Regenerative Medicine: Cell Biological and Technological Approaches. In: Greer EU: Trends in Stem Cell Research, Nova Science Publishers, Inc., NY, USA, 2005:67-101
  • Gerlach JC, Mutig K, Zeilinger K, Sauer IM, Mieder T, Naumann G, Gruenwald A, Pleß G, Schrade P, Efimova E, Goetz M, Mas A, Vienken J, Bachmann S, Neuhaus P: The use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors Ð a morphological study. Transplantation 2003, 76(5):781-786
  • Gerlach J, Zeilinger K, Grebe, A, Puhl G, PLess, G, Sauer I, Grunwald A, Schnoy N, Müller C, Neuhaus P. Recovery of Preservation-injured Primary Human Hepatocytes and Nonparenchymal Cells to Tissue-Like Structures in Large-Scale Bioreactors for Liver Support: An Initial TEM Study. Journal of Investigative Surgery 2003; 16(2):83-92
  • Gerlach J, Zeilinger K. Adult stem cell technology - prospects for stem cell based therapy. Int J Artif Org 2002 25; 2002: 83-90

  
  
• Organ preservation / Transplantation mediators
  
  Organ preservation / Transplantation mediators
  
  

  • Gerlach J, Jorres A, Nohr R, Zeilinger K, Spatkowski G, Neuhaus P. Local liberation of cytokines during liver preservation. Transpl Int 12; 1999: 261-265.
  • Zeilinger K, Tonnelier B, Tschesche A, Nehls W, Spatkowski G, Schindler R, Riedel E, Neuhaus P, Gerlach JC. Effect of energy substrates on the preservation outcome of hepatocytes and sinusoidal endothelial cells in an experimental hypoxia/reoxygenation model. Transplant Proc 29; 1997: 403-405.
  • Gerlach J, Jörres A, Schön M, Nohr R, Berger A, Spatkowski G, Smith MD, Neuhaus P. Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation. Transpl Int 1997; 10: 401-404
  • Gerlach JC, Hentschel F, Spatkowski G, Zeilinger K, Smith MD, Neuhaus P. Cell detachment during sinusoidal reperfusion after liver preservation - an in vitro model. Transplantation 1997; 64:907-912
  • Gerlach JC, Ziemer RA, Spatkowski G, Zeilinger K, Neuhaus P. Visualization of liver sinusoidal endothelial cell repair behavior after preservation by in vitro time-lapse video microscopy. Transplantation 1997;63:455-459
  • Zeilinger K, Tonnelier B, Tschesche A, Nehls W, Spatkowski G, Schindler R, Riedel E, Gerlach JC, Neuhaus P. Effect of energy substrates on the preservation outcome of hepatocytes and sinusoidal endothelial cells in an experimental hypoxia/reoxygenation model. Transplantation Proceedings 1997;29: 403-405
  • Gerlach J, Schön M, Berger A, Nohr R, Spatkowski G, Neuhaus P. Systemic liberaÂtion of interleukin-1_ and interleukin-1 receptor antagonist in the perioperative phase of liver transplantation. Transplant International 1996;9:408-414
  • Klöppel K, Gerlach J, Neuhaus P. Untersuchungen zur Wirkung von Puffersubstanzen in Leberkonservierungslösungen auf Hepatozyten in einem Modell der In-vitro-KonserÂvierung und Reoxygenierung. Langenbecks Archiv Chirurgie 1994;379:264-270
  • Klöppel K, Gerlach J, Neuhaus P. Untersuchungen zum Osmotikazusatz in LeberkonÂservierungslösungen in einem Modell der In-Vitro-Konservierung an Hepatozyten. LangenÂbecks Archiv Chirurgie 1994;379:329-334
  • Klöppel K, Gerlach J, Neuhaus P. Untersuchungen zur Elektrolytzusammensetzung von Leberkonservierungslösungen an Hepatozyten in einem Modell der In-Vitro-KonserÂvierung und Reoxygenierung. Langenbecks Archiv Chirurgie 1994;379:210-217
  • Gerlach J, Grehn S, Neuhaus P. Endothelial cell kinetics after anoxia and hypothermia in preservation solutions as indicators of endothelial repair. Transplantation Proceedings 1993;25:1593-1594
  • Gerlach J, Neuhaus P. Vergleich der in vitro Mitoseraten und der -Zellkinetik von portalÂvenösen Endothelzellen nach Hypothermie und Hypoxie in LeberkonservierungsÂlösunÂgen. Gall, Beger, Ungeheuer. Chir. Forum f. exp.u. klin. Forschung. Berlin/ Heidelberg 1992;381-386

  
  
• Alternatives to animal experiments
  
  Alternatives to animal experiments
  
  

  • Zeilinger K, Sauer IM, Pless G, Strobel C, Rudzitis J, Wang A, Nussler AK, Grebe A, Mao L, Auth SH, Unger J, Neuhaus P, Gerlach JC: Three-dimensional Co-culture of Primary Human Liver Cells in Bioreactors for In Vitro Drug Studies: Effects of the Initial Cell Quality on the Long-term Maintenance of Hepatocyte-specific Functions. Altern Lab Anim 2002, 30(5): 539-550
  • Nüssler AK, Wang A, Neuhaus P, Fischer J, Yuan J, Liu L, Zeilinger K, Gerlach J, Arnold PJ, Albrecht W. The suitability of hepatocyte culture models to study various aspects of drug metabolism. ALTEX 18/2; 2001: 91-101.
  • Zeilinger K, Auth S, Unger J, Grebe A, Mao L, Petrik M, Amalou Z, Appel K, Gerlach JC. Standardisierung eines Hepatozyten-Bioreaktorsystemes für in vitro-Metabolismusstudien als Alternative zum Tierversuch. In: Ersatz- und Ergänzungsmethoden zu Tierversuchen, ed.: H. Schöffl, H. Spielmann, HA Tritthart. Springer-Verlag/Wien 2000: 1-7
  • Zeilinger K, Auth S, Unger J, Grebe A, Mao L, Petrik M, Holland G, Appel K, Nüssler A, Neuhaus P, Gerlach J. Leberzellkultur in Bioreaktoren für in vitro Studien zum Arzneimittelmetabolismus als AlterÂnative zum Tierversuch. ALTEX 17/1; 2000: 3-10
  • Gerlach J. Long-term liver cell cultures in bioreactors and possible application for liver support. Cell biology and Toxicology 1997;13: 349-355
  • Gerlach J, Unger J, Hole O, Encke J, Müller Ch, Neuhaus P. Bioreaktor zum LangÂzeiterhalt differenzierter hepatischer Zellfunktionen für in vitro Wirkstoffprüfungen alterÂnativ zu Tierversuchen. ALTEX 1994;11:207-215
  • Köppel C, Tenczer J, Gerlach J. Die Problematik der endogenen Benzodiazepine in der forensischen Toxikologie. GTFCh Spurenanalyse, Heppenheim 1991;99-110
  • Schmidt HH, Nau H,Wittfoht W, Gerlach J, Prescher KE, Klein MM, Woyzella G, Niroomand F, Böhme E. Arginine is a physiological precursor of endothelium- derived nitric oxide. Eur J Pharmacol 1988;154:213-216
  • Unger JK, Kuehlein G, Schroers A, Gerlach JC, Roissant R. Adsorption of xenobiotics to plastic tubing incorporated into dynamic in vitro systems used in pharmacologic research. Biomaterials 2001;22: 2031-7

  
  
• Liver support / clinical
  
  Liver support / clinical
  
  

  • Sauer IM, Zeilinger K, Pless G, Kardassis D, Theruvath T, Pascher A, Mueller AR, Steinmueller T, Neuhaus P, Gerlach JC: Extracorporeal Liver Support based on Human Liver Cells and Albumin Dialysis Ð Treatment of a Patient with Primary Graft Non-Function. Gastroenterology 2003, Journal of Hepatology; 2003,39(4): 649-653
  • Irgang M, Sauer IM, Karlas A, Zeilinger K, Gerlach JC, Kurth R, Neuhaus P, Denner J: Porcine endogenous retroviruses (PERVs): No infection in patients treated with a bioreactor based on porcine liver cells. Clinical Virology 2003, J Clin Virol; 2003, 28(2): 141-154
  • Sauer IM, Kardassis D, Zeilinger K, Pascher A, Gruenwald A, Pless G, Irgang M, Kraemer M, Puhl G, Frank J, Müller AR, Steinmüller T, Denner J, Neuhaus P, Gerlach JC: Clinical extracorporeal hybrid liver support Ð phase I study with primary porcine liver cells. Xenotransplantation; 2003, in press
  • Gerlach J, Zeilinger K, Sauer IM, Mieder T, Nauman G, Grünwald A, Pless G, Holand A, Mas A, Vienken J, Neuhaus P. Extracorporeal liver support: Porcine or human cell based systems? Int J Artif Org 2002; 25 (10): 1013-1019
  • Sauer IM, Zeilinger K, Obermayer N, Pless G, Pascher A, Mieder T, Roth S, Goetz M, Kardassis D, Mas A, Neuhaus P, Gerlach JC. Primary human liver cells as source for modular extracorporeal liver support Ð a preliminary report. Int J Art Org 2002; 25 (10): 1001-1006
  • Sauer I, Gerlach J. Modular extracorporeal liver support. Art Org 2002; 26(8):703-706
  • Pascher A, Sauer IM, Hammer C, Gerlach JC, Neuhaus P: Extracorporeal Liver Perfusion as Hepatic Assist in Acute Liver Failure - A Review of World Experience. Xenotransplantation 2002; 9: 309-324.
  • Mundt A, Puhl G, Müller A, Sauer I, Müller C, Neuhaus P, Gerlach J. A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support. Int J Art Org 2002; 6: 542-548
  • Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schön M, Janke J, Puhl G, Unger J, Kraemer M, Busse B, Böhmer C, Belal R, Ingenlath M, Kosan M, Kosan B, Sültmann J, Patzold A, Tietze S, Roissant R, Müller C, Mönch E, Sauer IM, Neuhaus P. Experimental Evaluation of a Cell Module for Hybrid Liver Support. Int J Art Org 2001;24 (11):793-798
  • Bornemann R, Smith MD, Gerlach J. Consideration of potential immunological problems in the application of xenogenic hybrid liver support. Int J Art Org 1996;19:655-663
  • Gerlach J, Ziemer R, Neuhaus P: Fulminant liver failure: relevance of extracorporeal hybrid liver support systems. Int J Art Org 1996;19:7-13

  
  
• Liver support / experimental
  
  Liver support / experimental
  
  

  • Gerlach JC. Prospects of the use of hepatic cells for extracorporeal liver support. Acta Gastro-Enterologica Belgica 2005, Vol. LXVIII ;358-368
  • Sauer IM, Schwartländer R, Van der Jagt O, Steffen I, Efimova E, Pless G, Kehr DC, Kardassis D, Fruhauf JH, Gerlach JC, Neuhaus P. In vitro evaluation of the transportability of viable primary human liver cells originating from discarded donor organs in bioreactors. Artif Organs. 2005 Feb;29(2):144-51
  • Igor M. Sauer, Max Goetz, Ingo Steffen, Gesa Wlater, Daniel C. Kehr, Ruth Schwartländer, Yoon, J. Hwang, Andreas Pascher, Joerg C. Gerlach, Peter NeuhausIn Vitro Comparison of the Molecular Absorbent Recirculation system (MARS) and Single-pass Albumin Dialysis (SPAD). Journal of Hepatology 2004, 39(5): 1408-1414
  • Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schön M, Janke J, Puhl G, Unger J, Kraemer M, Busse B, Böhmer C, Belal R, Ingenlath M, Kosan M, Kosan B, Sültmann J, Patzold A, Tietze S, Roissant R, Müller C, Mönch E, Sauer IM, Neuhaus P. Experimental Evaluation of a Cell Module for Hybrid Liver Support. Int J Art Org 2001;24 (11):793-798
  • Busse B, Gerlach J. Bioreactors for Hybrid Liver support: Historical Aspects and novel designs. In: Hunkeler,D; Prokop, A; Cherrington, A; Rajotte, R; Sefton, M. Bioartificial Organs II, Technology, Medicine & Materials. Annals of the New York Acadamy of Sciences, 1999 (875): 326-339
  • Gerlach J, Trost T, Ryan CJ, Meißler M, Hole O, Müller C, Neuhaus P. Hybrid liver support system in a short term application on hepatectomized pigs. Int J Art Org 1994;17: 549-553
  • Gerlach J, Jörres A, Trost O, Hole O,Vienken J, Courtney JM, Gahl GM, Neuhaus P. Side effects of hybrid liver support therapy: TNF-a liberation in pigs, associated with extraÂcorporeal bioreactors. Int J Art Org 1993;16:604-608
  • Unger JK, Gerlach JC, Juhr NC, Roissant R. Development of a special cetheterbag to enable artificial organ evaluation in conscious unrestrained pigs: technical note. Int J Art Org 2000; 23: 268-274
  • Janke J, Gerlach J, Kardassis D, Böhmer C, Rossaint R. Effect of a hybrid liver support system on cardiopulmonary function in healty pigs. Int J Artif Org 1997; 20:570-576
  • Gleisner M, Bornemann R, Stemerowicz R, Meisler M, Neuhaus P, Gerlach J. Immunisolation of hybrid liver support systems by semipermeable membranes. Int J Artif Org 1997; 20: 644-649
  • Sauer I, Obermeyer N, Kardassis D, Theruvath T, Gerlach J. Development of a Hybrid Liver Support System. Bioartificial Organs III: Tissue Sourcing, Immunoisolation, and Clinical Trials (Editors: David Hunkeler, Alan Cherrington, Ales Prokop, and Ray Rajotte) Annals of the New York Academy of Sciences 2001, 944: 308-320 (ISBN: 1-57331-342-4)

  
  
• Skin cell-based therapies
  
  Skin cell-based therapies
  
  

  • Schlabe J, Johnen C, Schwartländer R, Moser V, Hartmann B, Gerlach JC,
  • Küntscher MV: Isolation and culture of different cell types from the human scalp tissue for development of skin substitute in spray technique. Burns 2007; 2599:1-9
  • Johnen C, Bräutigam K, Steffen I, Toman N , von Hesler F-W, Hartmann B, Ottomann C, A. Ekkernkamp A, Mehlitz T, Laurich O, Neuhaus P, Gerlach JC. Skin cell isolation for cell expansion is limited in patients using tobacco, alcohol, or are exhibiting diabetis mellitus. Burns 2006;32:194-200
  • Johnen C, Beichelt D, Witascheck T, Hartmann B, Steffen I, Toman N, Gerlach JC. Biodegradable transfer- membrane-based culture of human epidermal and dermal cells. Burns, submitted